Each year, PharmacyRx helps thousands of users save up to 80% on prescription medications ranging from blood thinners, to high blood pressure, to women’s health. In the world of medicine, certain drugs tend to be more frequently prescribed than others. These drugs often address common health concerns and conditions, making them in high demand. Here is a comprehensive list of the Top 50 most commonly prescribed drugs in 2022. These are the most popular drugs based on the most filled prescriptions through Most drugs are priced between $5 – $20.

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1. ) Click on any drug to find the Lowest Prices at over 35,000 Pharmacies.
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3. ) Show the Card to Pharmacist when ordering or picking up prescriptions.

Inform your Doctor to “E-Prescribe” your prescription to the Pharmacy of your choice.

  1. Vitamin D (Drisdol, Calciferol)
  2. Amoxicillin (Amoxil, Biomox, Polymox)
  3. Levothyroxine (Synthroid, Euthyrox, Levoxyl, Unithroid)
  4. Lisinopril (Prinivil, Zestril)
  5. Ibuprofen (Advil, Motrin)
  6. Amphetamine/dextroamphetamine (Adderall, Adderall XR)
  7. Amlodipine (Norvasc)
  8. Albuterol HFA (Ventolin HFA, Proair HFA, Proventil HFA)
  9. Prednisone (Deltasone, Rayos, Prednisone Intensol)
  10. Gabapentin (Neurontin)
  11. Benzonatate (Tessalon Perles)
  12. Alprazolam (Xanax)
  13. Cyclobenzaprine (Fexmid)
  14. Azithromycin (Zithromax Z-Pak)
  15. Atorvastatin (Lipitor)
  16. Cetirizine (Zyrtec)
  17. Losartan (Cozaar)
  18. Amoxicillin/clavulanate potassium (Augmentin)
  19. Cephalexin (Keflex)
  20. Metformin (Riomet)
  21. Metoprolol succinate ER (Toprol XL)
  22. Folic acid (Folvite)
  23. Hydrochlorothiazide (Microzide)
  24. Sildenafil citrate (Viagra, Revatio)
  25. Trazodone (Desyrel, Oleptro)
  26. Zolpidem tartrate (Ambien)
  27. Escitalopram oxalate (Lexapro)
  28. Clonazepam (Klonopin)
  29. Methylprednisolone (Medrol)
  30. Tadalafil (Cialis)
  31. Methocarbamol (Robaxin)
  32. Fluconazole (Diflucan)
  33. Sertraline (Zoloft)
  34. Doxycycline hyclate (Vibramycin, Acticlate, Targadox)
  35. Furosemide (Lasix)
  36. Fluoxetine (Prozac)
  37. Metronidazole (Vandazole, Metrogel, Flagyl)
  38. Freestyle Libre
  39. Omeprazole (Prilosec)
  40. FeroSul (ferrous sulfate)
  41. Sulfamethoxazole/trimethoprim (Bactrim)
  42. Phenobarbital (Luminal, Solfoton)
  43. Armour Thyroid (desiccated thyroid)
  44. Bromphen/pseudoephedrine/dextromethorphan (Bromfed DM)
  45. Metoprolol tartrate (Lopressor)
  46. Meloxicam (Mobic)
  47. Pantoprazole sodium (Protonix)
  48. Lisinopril/hydrochlorothiazide (Zestoretic)
  49. Estradiol (Estrace, Climara, Minivelle)
  50. Famotidine (Pepcid, Pepcid AC, Zantac 360)

It’s important to note that the most widely prescribed drugs may not be the best fit for every individual, and it’s crucial to consult with a healthcare provider before starting a new medication. Additionally, this list is not exhaustive and is based on the most recent data available.

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